2.  Enzymatic Acylation of 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol by Sol-Gel Entrapped Lipases

Authors: A. Cimporescu, A. Todea, V. Badea, C. Paul and F. Peter


Abstract:

Metoprolol, 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol, a selective adrenoceptor antagonist, was used as substrate for six native lipases from different sources for esterification. Three of the most efficient lipases, C. antarctica B, P. fluorescens and P. cepacia were subjected for immobilization by sol-gel entrapment using binary and ternary silane precursors systems. The highest operational stability was obtained by using sol-gel entrapped C. antractica B lipase obtained from a ternary mixture of silane precursors (PhTMOS:VTMOS:TMOS) at echimolar ratio during seven reaction cycles.


Keywords: metoprolol, lipase, sol-gel entrapment, trans-esterification

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