55.  Dyshomeostatic Effects of Nitrates from Drinking Water on Non-protein Nitrogen Metabolites in Leporides

Authors: G.D. Ghibu, G. Garban, C. Falca, C. Balta, V. Precob, Z. Garban


Abstract:

Studies on the action of nitrates present in environment (soil, water, foods) or used in food processing (as food additives) are of interest for their effects induced on the biochemical homeostasis in human and animals. An experimental animal model was designed in order to investigate the effect of nitrates on some serum parameters. In our experimental investigations rabbits were used in order to obtain information regarding changes in biochemical homeostasis. This model was chosen, taken into account the fact that rabbits are used as experimental animals and as food products. Sodium and magnesium nitrates in elevated concentrations as compared to the maximum contaminant level (MCL) - an indicator accepted by the internationally organizations - were administered to rabbits by drinking water. After the nitrates administration we determined the concentration of non-protein metabolites in rabbits’ serum i.e. uric acid, urea and creatinine. Two experimental groups - (EA), respectively (EB) were formed. In the drinking water of the animals from EA group - NaNO3 and of those from EB group - Mg(NO3)2 were introduced in high concentration - 20 fold higher the MCL value established in drinking water. Dyshomeostasis of serum non-protein nitrogen metabolites were revealed by the analytical results. The effects of nitrates action on the animal organism were reflected by results indicating a depression of uric acid quantum in both experimental groups. In the case of urea, a significant increase of its quantum was observed in both groups; in the case of creatinine the increase only in the EA group was significant.


Keywords: nitrates effects – rabbits, biochemical homeostasis of non-protein metabolites

PDF Version

 
 
Issues

Articles in Press
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2016
Volume 61(75), Issue 2, 2016
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2016
Volume 61(75), Issue 1, 2016
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2015
Volume 60(74), Issue 2, 2015
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2015
Volume 60(74), Issue 1, 2015
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2014
Volume 59(73), Issue 2, 2014
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2014
Volume 59(73), Issue 1, 2014
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2013
Volume 58(72), Issue 2, 2013
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2013
Volume 58(72), Issue 1, 2013
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2012
Volume 57(71), Issue 2, 2012
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2012
Volume 57(71), Issue 1, 2012
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2011
Volume 56(70), Issue 2, 2011
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2011
Volume 56(70), Issue 1, 2011
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2010
Volume 55(69), Issue 2, 2010
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2010
Volume 55(69), Issue 1, 2010
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2009
Volume 54(68), Issue 2, 2009
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2009
Volume 54(68), Issue 1, 2009
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2008
Volume 53(67), Issue 1 - 2, 2008
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2007
Volume 52(66), Issue 1 - 2, 2007
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2006
Volume 51(65), Item 1 - 2, 2006
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)


2005
Volume 50(64), Item 1 - 2, 2005
Chem. Bull. `POLITEHNICA` Univ. (Timisoara)



   
 
 
  © 2024 Industrial Chemistry and Environmental Engineering Faculty