Abstract:
Metoprolol, 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol, a selective adrenoceptor
antagonist, was used as substrate for six native lipases from different sources for esterification. Three of the most efficient
lipases, C. antarctica B, P. fluorescens and P. cepacia were subjected for immobilization by sol-gel entrapment using
binary and ternary silane precursors systems. The highest operational stability was obtained by using sol-gel entrapped C.
antractica B lipase obtained from a ternary mixture of silane precursors (PhTMOS:VTMOS:TMOS) at echimolar ratio
during seven reaction cycles.
Keywords:
metoprolol, lipase, sol-gel entrapment, trans-esterification
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